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Updated: Jul 13, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Alkyl carbon-nitrogen reductive elimination from platinum(IV)-sulfonamide complexes

Andrew V Pawlikowski1, April D Getty, Karen I Goldberg

  • 1Department of Chemistry, University of Washington, PO Box 351700, Seattle, Washington 98195-1700, USA.

Journal of the American Chemical Society
|August 4, 2007
PubMed
Summary

Platinum(IV) complexes with sulfonamide ligands undergo selective C-N or C-C bond formation via reductive elimination. Reaction conditions and solvent control the selectivity, enabling targeted synthesis of N-methylsulfonamides or ethane.

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