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Poly(caprolactone-co-oxo-crown ether)-based poly(urethane)urea for soft tissue engineering applications.

Eva Wisse¹, Raymond A E Renken, Jorg R Roosma

¹Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, NL-5600 MB Eindhoven, The Netherlands.

Biomacromolecules

|August 4, 2007

Summary

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New thermoplastic elastomers using poly(epsilon-caprolactone) and 2-oxo-12-crown-4 ether copolymers offer tunable properties for soft tissue engineering. These materials exhibit controlled degradation rates, making them promising for biomedical applications.

Area of Science:

Polymer Science
Biomaterials Engineering
Materials Science

Background:

Thermoplastic elastomers are crucial for soft tissue engineering.
Poly(epsilon-caprolactone) (PCL) is a common biomaterial, but its degradation rate can be slow.
Incorporating novel co-monomers can modify PCL properties for enhanced performance.

Purpose of the Study:

To synthesize and characterize poly(urethane)urea thermoplastic elastomers with varying soft segment compositions.
To investigate the impact of 2-oxo-12-crown-4 ether (OC) content on copolymer properties and mechanical performance.
To evaluate the degradation behavior of these novel elastomers for soft tissue engineering applications.

Main Methods:

Synthesis of random copolymers of epsilon-caprolactone (CL) and 2-oxo-12-crown-4 ether (OC).

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Characterization of soft segment crystallinity and mechanical properties (e.g., strain at break).

In vitro hydrolysis and degradation studies of the synthesized copolymers and poly(urethane)urea elastomers.

Main Results:

Increasing OC content reduced soft segment crystallinity and eliminated strain-induced crystallization.
Mechanical properties remained suitable for soft tissue engineering, with no reduction in strain at break.
Copolymers exhibited a higher intrinsic hydrolysis rate than PCL, with a significant increase observed when at least two adjacent OC units were present.

Conclusions:

The developed poly(CL-co-OC) copolymers are suitable soft segments for poly(urethane)urea thermoplastic elastomers.
An optimal OC:CL ratio can be determined for tailored degradation rates in soft tissue engineering.
Enhanced hydrophilicity and reduced crystallinity in poly(urethane)urea elastomers suggest increased in vivo degradation rates.