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Updated: Jul 13, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
Published on: September 15, 2010
Core-shell structures in single flexible-semiflexible block copolymers: finding the free energy minimum for the
Natsuhiko Yoshinaga1, Kenichi Yoshikawa
1Department of Physics, Graduate School of Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Abstract:
We investigate the folding transition of a single diblock copolymer consisting of a semiflexible and a flexible block. We obtain a Saturn-shaped core-shell conformation in the folded state, in which the flexible block forms a core and the semiflexible block wraps around it. We demonstrate two distinctive features of the core-shell structures: (i) The kinetics of the folding transition in the copolymer are significantly more efficient than those of a semiflexible homopolymer. (ii) The core-shell structure does not depend on the transition pathway.
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