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Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
Simulation study on the translocation of polymer chains through nanopores
Ying-Cai Chen1, Chao Wang, Meng-Bo Luo
1Department of Physics, Taizhou University, Taizhou 317000, China.
The Journal of Chemical Physics
|August 4, 2007
Summary
Polymer translocation through nanopores was simulated. Free energy barriers and chemical differences explain polymer behavior at different concentrations, with escaping time linked to chemical differences.
Area of Science:
- Polymer Physics
- Nanotechnology
- Computational Chemistry
Background:
- Understanding polymer chain translocation through nanopores is crucial for nanotechnology and biological processes.
- The behavior of polymers at varying concentrations influences translocation dynamics.
Purpose of the Study:
- To simulate polymer chain translocation through nanopores.
- To investigate the influence of free energy landscape, barriers, and chemical differences on translocation.
- To analyze the relationship between these factors and polymer concentration.
Main Methods:
- Dynamical Monte Carlo simulations were employed.
- The free energy landscape was calculated using a scanning method.
- The dependence of free energy barrier (Fb) and chemical difference (Deltamu) on chain concentration was analyzed.
Main Results:
- Free energy barrier (Fb) and chemical difference (Deltamu) explain polymer translocation behavior at low and high concentrations.
- The relationship between Deltamu and escaping time (tau(2)) aligns with theoretical predictions.
- Simulation results indicate relaxation time is dominated by Fb, while escaping time is dominated by Deltamu.
Conclusions:
- Concentration-dependent free energy parameters govern polymer translocation dynamics.
- Escaping time is primarily dictated by chemical differences, while relaxation time depends on free energy barriers.
