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Related Experiment Video

Updated: Jul 13, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Histiocytic sarcoma - a case with evenly distributed multinucleated giant cells.

Shun-Chen Huang1, Chia-Lo Chang, Cheng-Hua Huang

  • 1Department of Pathology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Rd, Niao-Sung Hasiang, Kaohsiung Hsien 833, Taiwan. shuang@cgmh.org.tw

Pathology, Research and Practice
|August 4, 2007
PubMed
Summary

Histiocytic sarcoma, a rare cancer, can present with numerous giant cells, mimicking other tumors. Accurate diagnosis requires detailed microscopic examination and immunohistochemistry.

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Histiocytic sarcoma is a rare malignant neoplasm of mature histiocytes.
  • It typically has a poor clinical prognosis.

Observation:

  • A unique case of true histiocytic sarcoma is presented, characterized by prominent multinucleated giant cells.
  • The tumor was situated in the abdominal cavity, causing severe adhesions.
  • Microscopic examination revealed mononuclear tumor cells and evenly distributed giant cells, with regional lymph node involvement.

Findings:

  • Immunohistochemical analysis showed tumor cells positive for lysozyme, CD68, and CD163.
  • The cells were negative for various lineage markers, including T-cell, B-cell, and melanocytic markers.
  • The findings highlight the diagnostic challenges posed by this rare presentation.

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Implications:

  • This case underscores the importance of comprehensive histopathological evaluation, including extensive immunostaining, for diagnosing challenging neoplasms.
  • Recognizing this variant is crucial for accurate differential diagnosis and appropriate patient management.
  • Further research into rare histiocytic sarcoma presentations can improve diagnostic accuracy and treatment strategies.