Multidisciplinary management of brain metastases

Area of Science:

• Neuro-oncology
• Neurosurgery
• Radiation Oncology

Background:

• Metastatic brain tumors are the most common intracranial neoplasms in adults.
• The incidence of brain metastases is increasing due to advanced imaging and systemic treatment.
• Current therapies include surgery, whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), and chemotherapy.

Purpose of the Study:

• To review key prognostic factors for guiding treatment selection.
• To discuss the roles of surgery, radiation, and chemotherapy in managing brain metastases.
• To present emerging therapeutic strategies for brain metastasis.

Main Methods:

• Review of clinical prognostic factors.
• Discussion of established treatment modalities (surgery, WBRT, SRS, chemotherapy).
• Exploration of novel and investigational therapies.

Main Results:

• Prognostic factors are crucial for maximizing survival and neurologic function.
• Multimodal treatment approaches are standard for brain metastases.
• New therapeutic directions are under active investigation.

Conclusions:

• Treatment decisions for brain metastases require careful consideration of prognostic factors.
• A multidisciplinary approach integrating surgery, radiation, and chemotherapy is essential.
• Future strategies aim to prolong survival, preserve function, and enhance quality of life.