Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statin use reduces decline in lung function: VA Normative Aging Study.

Stacey E Alexeeff1, Augusto A Litonjua, David Sparrow

  • 1Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, Landmark Center West, 415, 401 Park Drive, Boston, MA 02215, USA. sackerma@hsph.harvard.edu

American Journal of Respiratory and Critical Care Medicine
|August 4, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heated high flow nasal cannula flow rates in critical pediatric asthma: an observational cohort study.

The Journal of asthma : official journal of the Association for the Care of Asthma·2026
Same author

Intrapartum caesarean delivery and childhood BMI trajectories in relation to the infant gut microbiome in the VDAART prospective birth cohort.

EBioMedicine·2026
Same author

Maternal Body Mass Index Attenuates Response to High-Dose Vitamin D Supplementation During Pregnancy: A Secondary Analysis of the VDAART Randomized Trial.

The Journal of nutrition·2026
Same author

Maternal and perinatal nutritional programming of lung health and disease in childhood and early adulthood: Research gaps and opportunities-National Heart, Lung, and Blood Institute/National Institutes of Health Workshop Report.

The Journal of allergy and clinical immunology·2026
Same author

Prenatal Vitamin D, childhood wheeze, asthma, and lung function: Results from the Vitamin D Antenatal Asthma Reduction Trial (VDAART).

The Journal of steroid biochemistry and molecular biology·2026
Same author

Maternal 12-HETE is associated with childhood asthma and the responses to prenatal omega-3 supplementation.

Cell reports. Medicine·2026
Same journal

When an Exacerbation Signals a Different Future in non-severe asthma.

American journal of respiratory and critical care medicine·2026
Same journal

Aim High-Stay Stable: Rethinking Treatment Success in COPD.

American journal of respiratory and critical care medicine·2026
Same journal

Three versus six weeks of corticosteroids for mild immune-related pneumonitis: a randomized trial.

American journal of respiratory and critical care medicine·2026
Same journal

Signal in the Noise: Polygenic Scores and the Problem of Defining Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine·2026
Same journal

Do mtDNA fragmentomic peaks reflect cancer biology or preanalytical and technical artifacts in NSCLC?

American journal of respiratory and critical care medicine·2026
Same journal

Short for Their Age: Interpreting Whole-Genome Telomere Length in Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine·2026
See all related articles

Statin use slows lung function decline in elderly men. The benefit is greater in current smokers compared to never-smokers or former smokers.

Area of Science:

  • Gerontology
  • Pulmonology
  • Pharmacology

Background:

  • Decreased lung function is associated with inflammation and oxidative stress.
  • Statins possess anti-inflammatory and antioxidant properties.

Purpose of the Study:

  • To investigate the impact of statin use on lung function decline in the elderly.
  • To determine if smoking status modifies the effect of statins on lung function.

Main Methods:

  • Analysis of 2,136 lung function measurements (FVC and FEV1) from 803 elderly men (Normative Aging Study, 1995-2005).
  • Mixed linear models used to assess the effects of statin use and smoking status on lung function decline.
  • Covariate adjustments made for subject and potential confounders.

Main Results:

Related Experiment Videos

  • Statin users showed a slower decline in FEV1 (10.9 ml/year) compared to non-users (23.9 ml/year).
  • A significant interaction was observed between time, statin use, and smoking status (P < 0.001).
  • Statins demonstrated a beneficial effect across all smoking groups, with varying degrees of improvement.

Conclusions:

  • Statin use attenuates the decline in lung function in elderly individuals.
  • The magnitude of the beneficial effect of statins on lung function is influenced by smoking status.