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Hairy cell leukemia

Ronan Swords1, Francis Giles

  • 1Department of Haematology, University College Hospital Galway, Galway, Ireland.

Medical Oncology (Northwood, London, England)
|August 4, 2007
PubMed

Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder characterized by pancytopenia and variable infiltration of the reticuloendothelial system with "hairy" lymphocytes. HCL is more common in men than women and has a median age of diagnosis of 52 yr. Typically, patients with HCL respond well to purine analog-based therapy. The purpose of this review will be to establish the current status of HCL with respect to its pathophysiology, diagnosis, management, and future directions.

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