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Updated: Jul 13, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Prevalence and determinants of cognitive impairment in chronic heart failure patients
Stéphanie Debette1, Christophe Bauters, Didier Leys
1Department of Cardiology, University Hospital of Lille, Lille, France.
Insights
Cognitive impairment is common in patients hospitalized for chronic heart failure (CHF) decompensation. This condition affects patients regardless of their history of stroke or transient ischemic attack, highlighting a significant link between heart and brain health.
Area of Science:
- Cardiology
- Neurology
- Geriatrics
Background:
- Chronic heart failure (CHF) is a complex condition with multifaceted impacts on patient health.
- Cognitive impairment is an understudied complication in CHF patients, particularly during decompensation events.
- Understanding cognitive function in CHF is crucial for comprehensive patient management.
Purpose of the Study:
- To determine the prevalence of cognitive impairment in patients hospitalized for CHF decompensation.
- To identify factors associated with cognitive impairment in this patient population.
- To explore the relationship between CHF severity and cognitive function.
Main Methods:
- Prospective study involving 83 patients hospitalized for CHF decompensation.
- Utilized the Folstein Mini-Mental State Examination (MMSE) to assess cognitive function.
- Administered questionnaires to gather data on cerebrovascular accidents (CVA) and transient ischemic attacks (TIA).
Main Results:
- A significant proportion of patients exhibited cognitive impairment (61% with MMSE ≤ 28, 31% with MMSE < 24).
- Factors associated with lower MMSE scores included atrial fibrillation/flutter, NYHA class IV, and higher education levels.
- Cognitive impairment was prevalent even when excluding patients with a history of CVA or TIA.
Conclusions:
- Cognitive impairment is frequent in CHF decompensation patients, irrespective of cerebrovascular history.
- The severity of cognitive impairment appears to correlate with the severity of CHF.
- Further research is needed to investigate the impact of cognitive impairment on treatment adherence and outcomes in CHF.
Abstract:
Cognitive impairment has seldom been investigated in patients with chronic heart failure (CHF). The authors' aim was to assess the prevalence and determinants of cognitive impairment in patients hospitalized for CHF decompensation. The authors prospectively performed the Folstein Mini-Mental State Examination (MMSE) and completed a standardized questionnaire for cerebrovascular accidents (CVA) and transient ischemic attacks (TIA) in patients hospitalized for CHF decompensation during a 3-month period. A total of 83 patients were studied: 15 had a history of CVA or TIA, 51 (61%) had an MMSE score < or = 28 (or < or = 26 if schooling < or = 8 years), and 26 (31%) had an MMSE score <24. Factors associated with an MMSE score <24 were atrial fibrillation/flutter (odds ratio [OR], 8.1; 95% confidence interval [CI], 1.9-34.6), New York Heart Association functional class IV (OR, 4.1; CI, 1.0-16.4), and schooling >8 years (OR, 0.2; CI, 0.0-0.8). Adjusting for history of CVA or TIA or excluding patients with a history of CVA or TIA did not affect the findings. Cognitive impairment is frequent in patients hospitalized for CHF decompensation whether or not they have a past history of CVA or TIA. The severity of cognitive impairment parallels that of CHF. The question of whether this cognitive impairment decreases adherence to treatment and contributes to a worse outcome in CHF patients should be explored.
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