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Urinary Bladder

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

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Related Experiment Video

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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

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Published on: August 9, 2012

Tunica repair with acellular bladder matrix maintains corporal tissue function.

D Eberli¹, R Susaeta, J J Yoo

¹Department of Urology and Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.

International Journal of Impotence Research

|August 4, 2007

Summary

A novel acellular bladder matrix (ABM) shows promise for penile reconstructive surgery. This collagen-based biomaterial is biocompatible, durable, and functionally effective for tunica albuginea repair.

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Area of Science:

Urology
Biomaterials Science
Regenerative Medicine

Background:

Penile reconstructive surgery for conditions like Peyronie's disease or tumor resection necessitates tunica albuginea repair.
Existing biomaterials for tunica albuginea repair lack comprehensive functional data.

Purpose of the Study:

To evaluate the applicability and functional outcomes of an acellular bladder matrix (ABM) as a biomaterial for tunica albuginea repair.

Main Methods:

Biocompatibility testing (metabolic activity, viability, apoptosis) of the ABM.
Surgical implantation of ABM patches into the dorsal tunica albuginea of 24 rabbits.
Post-operative assessment including cavernosometry, cavernosography, biomechanical analysis, and histological examination at 1, 2, and 3 months.

Main Results:

The ABM demonstrated excellent biocompatibility with no adverse effects, inflammation, or infection.
Cavernosometry and cavernosography revealed normal erectile function and anatomical configuration.
Biomechanical analysis showed tensile strength comparable to native tunica albuginea, with minimal, decreasing inflammatory response over time.

Conclusions:

Acellular bladder matrix (ABM) is a biocompatible, durable, and effective substitute for tunica albuginea repair.
ABM holds potential as an off-the-shelf biomaterial for patients requiring penile reconstructive surgery.