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Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
Published on: June 8, 2017
Neonatal hearing screening model: an Italian regional experience
M G Calevo1, P Mezzano, E Zullino
1Epidemiology and Biostatistics Service, G. Gaslini Institute, Genoa, Italy. mariagraziacalevo@ospedale-gaslini.ge.it
Summary
A new model for newborn hearing screening was developed and piloted. This comprehensive approach aims to improve early diagnosis and rehabilitation for congenital hearing impairment in infants.
Area of Science:
- Audiology
- Public Health
- Pediatrics
Background:
- Congenital hearing impairment affects a significant number of newborns.
- Early detection and intervention are crucial for optimal developmental outcomes.
- Existing hearing screening programs may lack comprehensive integration of diagnostic and rehabilitative services.
Purpose of the Study:
- To develop and evaluate a model for routine, centralized hearing screening for all newborns in a region.
- To integrate all aspects of hearing screening, from initial diagnosis to psychological support and early rehabilitation.
- To assess the feasibility and resource requirements for implementing such a model.
Main Methods:
- A prospective observational study was conducted in the Liguria region of Italy.
- A four-phase model was designed, encompassing administrative, screening, therapeutic, and epidemiological aspects.
- A pilot study was performed on infants born in selected regional birth centers to test feasibility and workload.
Main Results:
- During the pilot, 99.1% of 3268 newborns were screened using otoacoustic emissions (OAE).
- OAE showed a 'pass' in 98.2% and 'refer' in 1.8% of infants.
- Auditory brainstem response (ABR) testing was conducted on high-risk infants and those who 'referred' OAE, with 45 positive or uncertain results.
Conclusions:
- The pilot study results supported the feasibility of the proposed hearing screening model.
- The model offers a framework for regional organizations to enhance care quality through rationalization and optimization.
- This approach facilitates improved diagnosis, management, and rehabilitation for congenital hearing impairment.

