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Bronchorrhoea.

M Lopez-Vidriero, J Charman, E Keal

    Thorax
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Bronchorrhea, characterized by excessive sputum production, has distinct sputum properties differentiating it from hypersalivation. Sputum analysis reveals unique rheological and chemical profiles, aiding in diagnosis.

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    Area of Science:

    • Pulmonary Medicine
    • Biochemistry

    Background:

    • Bronchorrhea is defined by excessive daily sputum production (>100 ml).
    • Distinguishing bronchorrhea from hypersalivation requires understanding sputum characteristics.

    Purpose of the Study:

    • To characterize the rheological and chemical properties of bronchorrhea sputum.
    • To establish differential diagnostic markers for bronchorrhea.

    Main Methods:

    • Analysis of sputum viscosity, dry weight, N-acetyl neuraminic acid (NANA), fucose, and sulphate.
    • Comparison of bronchorrhea sputum with saliva and sputum from chronic lung diseases.

    Main Results:

    • Bronchorrhea sputum properties fall between saliva and chronic lung disease sputum.
    • Sputum NANA, fucose, and sulphate levels are higher in bronchorrhea than saliva.

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  • Bronchorrhea sputum is low in acid glycoprotein but shows increased viscosity over time and two-phase separation.

    • Conclusions:

    • Sputum rheological and chemical analysis can differentiate bronchorrhea from hypersalivation.
    • Specific sputum markers aid in the differential diagnosis of bronchorrhea.
    • Steroid therapy may be effective in some bronchorrhea cases, especially with low NANA levels.