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Oxidant and antioxidant parameters in the treatment of meningitis

Ali Aycicek1, Akin Iscan, Ozcan Erel

  • 1Pediatric Service, Sanliurfa Children's Hospital, Medical Faculty, Harran University, Sanliurfa, Turkey. ali_aycicek@yahoo.com.tr

Pediatric Neurology
|August 7, 2007
PubMed

Insights

Treatment for bacterial meningitis in children reduces serum oxidative stress but increases oxidative stress in the cerebrospinal fluid. This study highlights the complex impact of treatment on oxidant and antioxidant balance.

Area of Science:

  • Biochemistry
  • Pediatric Infectious Diseases
  • Neurology

Background:

  • Bacterial meningitis is a serious infection affecting children.
  • Oxidative stress plays a role in the pathogenesis of bacterial meningitis.
  • Understanding the impact of treatment on oxidative balance is crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the effects of bacterial meningitis treatment on serum and cerebrospinal fluid oxidant-antioxidant status in children.
  • To compare oxidative and antioxidant markers before and after treatment in pediatric patients.

Main Methods:

  • Collected serum and cerebrospinal fluid from 40 children with bacterial meningitis before and after treatment.
  • Collected serum from 37 healthy children as controls.
  • Assessed levels of total oxidant status, lipid hydroperoxide, oxidative stress index, uric acid, albumin, ceruloplasmin, total antioxidant capacity, vitamin C, total bilirubin, and catalase.

Main Results:

  • Serum oxidative stress markers (total oxidant status, lipid hydroperoxide, oxidative stress index) were significantly lower after treatment compared to before treatment.
  • Cerebrospinal fluid oxidative stress markers were significantly higher after treatment than before treatment.
  • Serum and cerebrospinal fluid antioxidant markers showed variable changes, with some not significantly altered by treatment.

Conclusions:

  • Bacterial meningitis treatment leads to decreased oxidative stress in serum but increased oxidative stress in cerebrospinal fluid in children.
  • The findings suggest a complex interplay between treatment and the oxidant-antioxidant system in the central nervous system during bacterial meningitis recovery.

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