Related Experiment Video
Updated: Jul 13, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
CCH cells are potent stimulators in the allogeneic mixed leucocyte reaction
S J Baines1, B A Blacklaws, E McInnes
1Centre for Veterinary Science, University of Cambridge, Madingley Road, Cambridge, CB3 0PQ, United Kingdom. sbaines@rvc.ac.uk
Abstract:
Canine cutaneous histiocytoma (CCH) has been identified as a tumour of epidermal Langerhans cells (LCs) on the basis of immunophenotypic studies. Neoplastic Langerhans cells (CCH-LCs) were isolated from lesions of canine cutaneous histiocytoma. The CCH-LC cells expressed CD1b, CD11/18, CD45, MHC-I, and MHC-II. The CCH-LC cells were potent stimulators of the mixed leucocyte reaction (MLR) in vitro when compared to PBMCs from the tumour-bearing animals. This provides evidence that the neoplastic cells in CCH have functional as well as immunophenotypic characteristics of Langerhans cells.
Related Concept Videos
Differentiation of Common Myeloid Progenitor Cells
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...

