Related Experiment Videos
Prognostic factors in primary gastrointestinal leiomyosarcoma: a retrospective study
H Kimura1, Y Yonemura, N Kadoya
1Department of Surgery, School of Medicine, Kanazawa University, Japan.
World Journal of Surgery
|November 1, 1991
Summary
Aggressive surgical resection of gastrointestinal leiomyosarcomas is effective, even for recurrent tumors. Tumor site, size, and DNA ploidy impact prognosis, with local recurrences and distant metastases significantly affecting survival.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Gastrointestinal leiomyosarcomas are rare tumors.
- Prognostic factors for these tumors require further elucidation.
Purpose of the Study:
- To analyze clinico-pharmacologic variables affecting prognosis in gastrointestinal leiomyosarcomas.
- To evaluate the efficacy of surgical resection for recurrent tumors.
Main Methods:
- Retrospective analysis of 36 patients undergoing surgical resection for gastrointestinal leiomyosarcomas.
- Evaluation of tumor site, size, cellularity, mitotic index, and DNA ploidy.
- Correlation of these factors with patient survival and recurrence patterns.
Main Results:
- Distant metastases and/or recurrences were observed in 41% of patients, predominantly hematogenous.
- Local recurrences/distant metastases, tumor site, tumor size, surgical treatment, and DNA ploidy pattern significantly correlated with survival.
- Mitotic index and cellularity did not show significant correlation with survival.
- Some patients with recurrent tumors achieved long-term survival after repeat resection.
Conclusions:
- Tumor site, size, and DNA ploidy are significant prognostic indicators for gastrointestinal leiomyosarcomas.
- Aggressive surgical resection, including for recurrent disease, can be an effective treatment strategy.