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Updated: Jul 13, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
Modern concept of vascular cognitive impairment
1Department of Clinical Neurosciences, Royal Free & University College Medical School, Hampstead Campus, Rowland Hill St., London NW3 2PF, UK. j.gbowler@ucl.ac.uk
Background:
Vascular cognitive impairment (VCI) has superseded vascular dementia and multi-infarct dementia as the concept to be used in cognitive decline due to cerebrovascular disease.
Method:
The literature was reviewed with regard to the concept of VCI and its incidence, pathophysiological substrate, clinical features and management.
Results:
A change in the diagnostic paradigm from the current Alzheimer-based definition of vascular dementia to VCI will allow the earlier identification of cases and will identify a different population from that recognized using the current criteria for vascular dementia.
Conclusions:
Case identification at the earliest possible stage affords the greatest opportunity for treatment that may slow the rate of progression.
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