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Updated: Jul 13, 2026

Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells
Published on: September 26, 2018
Cell type-specific gating of perisomatic inhibition by cholecystokinin
Csaba Földy1, Soo Yeun Lee, János Szabadics
1Department of Anatomy and Neurobiology, University of California, Irvine, California 92697-1280, USA. cfoldy@uci.edu
Abstract:
Parvalbumin- and cholecystokinin (CCK)-expressing basket cells provide two parallel, functionally distinct sources of perisomatic inhibition to postsynaptic cells. We show that exogenously applied CCK enhances the output from rat parvalbumin-expressing basket cells, while concurrently suppressing GABA release from CCK-expressing neurons through retrograde endocannabinoid action. These results indicate that CCK may act as a molecular switch that determines the source of perisomatic inhibition for hippocampal principal cells.
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