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A comparison of complication rates based on published haemovigilance data
1Blood Bank, Asker and Baerum Hospital, 83, 1309 Rud, Norway. oystein.flesland@sabhf.no
Intensive Care Medicine
|November 2, 2007
Summary
Haemovigilance systems reveal significant differences in transfusion reaction rates between countries, particularly for thrombocyte concentrates. Solvent detergent-treated plasma shows a very low rate of immunological complications, including TRALI.
Area of Science:
- Transfusion Medicine
- Immunology
- Public Health Surveillance
Background:
- Haemovigilance systems are crucial for monitoring transfusion safety and identifying areas for improvement.
- Comparing international data highlights differences in transfusion practices and outcomes.
Purpose of the Study:
- To analyze immunological transfusion complications, focusing on Transfusion-Related Acute Lung Injury (TRALI), using haemovigilance reports from Denmark, Norway, Sweden, and the UK.
- To compare transfusion reaction rates and identify potential product-related safety differences between countries.
Main Methods:
- Review and analysis of national haemovigilance reports from Denmark, Norway, Sweden, and the UK.
- Comparative analysis of reported immunological transfusion complications, including TRALI, stratified by blood product type.
Main Results:
- Norway reported high rates of immunological transfusion reactions for red blood cells (RBC) and thrombocyte concentrates (Trc).
- Denmark and the UK showed similar rates for RBC and fresh frozen plasma (FFP) but differed significantly for Trc.
- FFP was implicated in 49% of TRALI cases, while no TRALI cases were reported after solvent detergent-treated (SD) plasma transfusion.
Conclusions:
- Significant variations in thrombocyte concentrate reactions between Denmark and the UK suggest differences in production methods.
- Solvent detergent-treated plasma appears to have a very low incidence of immunological complications, including TRALI.
- Haemovigilance data is valuable for selecting safer blood products and improving transfusion safety.
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