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Related Experiment Videos

Initial studies on "six months disease" in sheep.

S Pyakural, N B Singh

    The Veterinary Record
    |January 17, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Enterotoxaemia in sheep, caused by Clostridium welchii type D, was confirmed in Nepal. Most isolates produced key toxins, linking "Six months disease" to enterotoxaemia.

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    Area of Science:

    • Veterinary Microbiology
    • Animal Pathology

    Background:

    • Enterotoxaemia is a significant disease in sheep.
    • Clostridium welchii type D is a known causative agent.
    • Field investigations in Nepal suggested its presence.

    Purpose of the Study:

    • To confirm and characterize Clostridium welchii type D isolates from sheep in Nepal.
    • To investigate the epidemiological link between local disease names and enterotoxaemia.

    Main Methods:

    • Isolates were characterized using morphological, cultural, biochemical, and toxin-producing assays.
    • Anaerobic meat medium was used to assess meat discoloration.
    • Fermentation patterns and toxin production (alpha and epsilon) were analyzed.

    Main Results:

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    • All investigated isolates of Clostridium welchii type D produced pinkish discoloration in anaerobic meat medium.
    • Most strains fermented lactose, maltose, dextrose, and sucrose; salicin fermentation varied.
    • 166 out of 200 isolates produced both alpha and epsilon toxins, indicating toxigenicity.

    Conclusions:

    • The study confirmed Clostridium welchii type D enterotoxaemia in Nepalese sheep.
    • "Six months disease" is epidemiologically identified as enterotoxaemia.
    • A significant proportion of isolates were toxigenic, producing alpha and epsilon toxins.