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DRG11 immunohistochemical expression during embryonic development in the mouse.

Sandra Rebelo1, Carlos Reguenga, Liliana Osório

  • 1Laboratory of Molecular Cell Biology, Faculty of Medicine of Oporto and IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|August 7, 2007
PubMed
Summary

DRG11, a transcription factor, is crucial for developing pain pathways in the nervous system. Its expression pattern reveals its role in forming early sensory circuits from embryonic stages through early postnatal development.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • DRG11 is a paired domain transcription factor essential for nociceptive circuitry assembly in the spinal cord dorsal horn.
  • It is expressed in small dorsal root ganglion (DRG) neurons and their spinal cord projection areas.
  • DRG11 knockout mice display structural and neurochemical deficits and reduced nociceptive responses.

Purpose of the Study:

  • To generate a polyclonal antibody against DRG11.
  • To perform a detailed spatio-temporal analysis of DRG11 expression during neural development.

Main Methods:

  • Generation of a polyclonal antibody against DRG11.
  • Systematic spatio-temporal analysis of DRG11 expression using the antibody.

Main Results:

  • DRG11 expression was detected from E10.5 in the spinal dorsal horn, DRG, and trigeminal ganglion, persisting until P14-21.
  • Cranial expression was observed from E10.5 in sensory ganglia and brain nuclei until early postnatal ages.
  • The spatio-temporal data provide insights into DRG11's role during development.

Conclusions:

  • DRG11 plays a significant role in the establishment of the initial neuronal sensory relay during development.
  • Its expression pattern supports its function in the formation of sensory pathways.