Related Experiment Video
Updated: Jul 13, 2026

In Situ Hybridization Techniques for Paraffin-Embedded Adult Coral Samples
Published on: August 31, 2018
Cytotoxic diterpenoids from the hybrid soft coral Sinularia maxima x Sinularia polydactyla
Haidy Nasr Kamel1, Daneel Ferreira, Luis F Garcia-Fernandez
1Department of Pharmacognosy, and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA. hnkamel@olemiss.edu
Abstract:
Chemical investigation of the hybrid soft coral Sinularia maxima x Sinularia polydactyla yielded four new cembranolide diterpenes (1-4), the norcembranoid 5-episinuleptolide (5), and two known sesquiterpenes. The structures and configurations of the new compounds were determined by spectroscopic techniques and comparison of NMR data with those of related metabolites. Compound 3 shows strong cytotoxicity on the breast cancer SK-BR3 cell line and cervix cancer HeLa and HeLa-Apl cell lines with GI(50) values of 0.039, 0.48, and 0.56 microM, respectively.
Related Concept Videos
Red Algae
Diversity of Protists II

