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Polymer translocation through a nanopore under a pulling force.

Ilkka Huopaniemi¹, Kaifu Luo, Tapio Ala-Nissila

¹Laboratory of Physics, Helsinki University of Technology, P.O. Box 1100, FIN-02015 TKK, Espoo, Finland.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

|August 7, 2007

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This study reveals polymer translocation dynamics through nanopores. Increased pulling force (F) and chain length (N) impact translocation time (tau), showing distinct regimes for different force strengths.

Area of Science:

Polymer physics
Nanotechnology
Computational biophysics

Background:

Polymer translocation through nanopores is crucial for DNA sequencing and drug delivery.
Understanding the factors influencing translocation speed and time is essential for optimizing these applications.
Previous studies have explored various driving forces and pore geometries.

Purpose of the Study:

To investigate the influence of chain length (N) and pulling force (F) on polymer translocation time (tau) through a nanopore.
To analyze the different regimes of translocation dynamics under varying forces.
To examine the waiting time distribution for monomer exit.

Main Methods:

Langevin dynamics simulations were employed to model polymer translocation.

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System parameters included polymer chain length (N) and applied pulling force (F).

Analysis focused on translocation time (tau) and translocation velocity (v).

Main Results:

Translocation time (tau) scales approximately as N^2, and velocity (v) scales as N^-1 for moderate to strong forces.
Three regimes of tau dependence on F were observed for wide pores: F-independent (weak F), F^(-2+1/nu) (moderate F), and F^-1 (strong F), where nu is the Flory exponent.
For narrow pores, tau scales as F^-1 even for moderate forces.

Conclusions:

The study provides a detailed understanding of polymer translocation dynamics influenced by chain length and pulling force.
The identified scaling relationships offer predictive power for nanopore-based technologies.
The findings highlight differences in translocation behavior between wide and narrow pores.