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Updated: Jul 13, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Model for Osteosarcoma-9 as a potent factor in cell survival and resistance to apoptosis
Ekaterini Vourvouhaki1, Carla Carvalho, Paulo Aguiar
1Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 115 21 Athens, Greece.
Abstract:
In this paper we use a simple model to explore the function of the gene Osteosarcoma-9 (OS-9). We are particularly interested in understanding the role of this gene as a potent anti-apoptotic factor. The theoretical description is constrained by experimental data from induction of apoptosis in cells where OS-9 is overexpressed. The data available suggest that OS-9 promotes cell viability and confers resistance to apoptosis, potentially implicating OS-9 in the survival of cancer cells. Three different apoptosis-inducing mechanisms were tested and are modeled here. A more complex and realistic model is also discussed.
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