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Related Experiment Videos

Concentric nuclear inclusions.

M Itabashi, Z Hruban, T W Wong

    Virchows Archiv. B, Cell Pathology
    |March 9, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Concentric lamellar inclusions were identified in the nuclei of pancreatic and parotid acinar cells. These structures are proposed to originate from nuclear-sequestered rough endoplasmic reticulum cisternae.

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    Area of Science:

    • Cell Biology
    • Pathology
    • Electron Microscopy

    Background:

    • Nuclear inclusions can indicate cellular stress or disease.
    • Membrane-bound structures within the nucleus are uncommon and warrant investigation.

    Purpose of the Study:

    • To describe and propose an origin for unique membrane-bound concentric lamellar inclusions found in the nucleus of acinar cells.

    Main Methods:

    • Electron microscopy was used to examine nuclear inclusions in pancreatic and parotid acinar cells.
    • Histopathological analysis of patient samples.

    Main Results:

    • Membrane-bound concentric lamellar inclusions were observed in the nuclei of pancreatic acinar cells from a patient with multiple neoplasms.
    • Similar inclusions were found in parotid acinar cells of a patient with systemic lupus erythematosus.

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    Conclusions:

    • The findings suggest that these nuclear inclusions may form from rough endoplasmic reticulum cisternae that have become sequestered within the nucleus.
    • This phenomenon may be associated with specific pathological conditions.