Dalbavancin, a long-acting lipoglycopeptide for the treatment of multidrug-resistant Gram-positive bacteria

Related Experiment Video

Updated: Jul 13, 2026

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
11:28

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

Jean-Winoc Decousser1, Nadège Bourgeois-Nicolaos, Florence Doucet-Populaire

  • 1Department of Biology, Centre Hospitalier de Dourdan, Dourdan, France. jean-winoc.decousser@wanadoo.fr

Expert Review of Anti-Infective Therapy
|August 7, 2007
PubMed

Insights

Dalbavancin, a novel lipoglycopeptide antibiotic, shows high potency against serious Gram-positive infections, including methicillin-resistant Staphylococcus aureus. Clinical trials confirm its efficacy and safety for skin infections and bacteremia.

Area of Science:

  • Pharmacology and Infectious Diseases
  • Clinical Microbiology
  • Antibiotic Development

Background:

  • Dalbavancin is a lipoglycopeptide antibiotic developed for serious infections.
  • It exhibits potent in vitro activity against key Gram-positive pathogens.
  • Established antibiotics like vancomycin serve as benchmarks for efficacy.

Purpose of the Study:

  • To evaluate the clinical efficacy and safety of dalbavancin.
  • To compare dalbavancin's effectiveness against other antibiotics.
  • To explore potential applications of dalbavancin in various infections.

Main Methods:

  • Phase II/III clinical trials for complicated skin and skin structure infections.
  • Comparative efficacy studies against linezolid and vancomycin.
  • Phase II study for catheter-related bacteremia.

Main Results:

  • Dalbavancin demonstrated clinical efficiency in complicated skin and skin structure infections.
  • It was found to be as effective as linezolid or vancomycin, including against methicillin-resistant Staphylococcus aureus.
  • Efficacy was also shown in a study of catheter-related bacteremia.

Conclusions:

  • Dalbavancin is an effective treatment option for serious Gram-positive infections.
  • Its efficacy is comparable to existing therapies, offering a potential new therapeutic choice.
  • Further research suggests potential utility in infections like endocarditis and osteitis.

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