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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
What is the Cell Cycle?01:04

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...

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Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
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Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Published on: September 17, 2012

A data integration approach for cell cycle analysis oriented to model simulation in systems biology.

Roberta Alfieri1, Ivan Merelli, Ettore Mosca

  • 1Istituto di Tecnologie Biomediche - Consiglio Nazionale delle Ricerche, via F,lli Cervi 93, Segrate (Milano), Italy. roberta.alfieri@itb.cnr.it

BMC Systems Biology
|August 7, 2007
PubMed
Summary

This study introduces the Cell Cycle Database, a resource for systems biology research that integrates gene and protein data with mathematical models. It aids in analyzing cell cycle dynamics and cancer-related biological processes.

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

Area of Science:

  • Systems Biology
  • Computational Biology
  • Molecular Biology

Background:

  • The cell cycle is a fundamental biological process crucial for understanding cancer.
  • Systems biology approaches, including mathematical modeling, are vital for dissecting complex biological networks.
  • Data integration and accurate modeling are essential for advancing cell cycle research.

Purpose of the Study:

  • To present the Cell Cycle Database, a resource supporting systems biology analysis of the cell cycle.
  • To integrate diverse information on cell cycle genes, proteins, and interaction networks.
  • To facilitate mathematical simulations of cell cycle component behavior.

Main Methods:

  • Developed a comprehensive database integrating gene, protein, and mathematical model information for yeast and mammalian cell cycles.
  • Created a web interface for easy browsing of cell cycle-related data.
  • Implemented a computational pipeline for solving ordinary differential equation systems describing the cell cycle.

Main Results:

  • The Cell Cycle Database provides integrated information on cell cycle components and their interactions.
  • The system enables mathematical simulations to analyze the quantitative behavior of cell cycle elements over time.
  • Users can retrieve information and analyze dynamical properties of cell cycle models.

Conclusions:

  • The Cell Cycle Database is a freely available resource promoting systems biology research on the cell cycle.
  • It addresses key challenges in systems biology: data integration and mathematical simulation of critical biological processes.
  • The resource aids in identifying system-level properties like steady states and oscillations by combining structural and dynamic data.