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Association between RANTES polymorphisms and asthma severity among Tunisian children
Jihene Lachheb1, Hanene Chelbi, Kamel Hamzaoui
1Medicine University of Tunis, Homeostasis and cell Dysfunction Unit Research 99/UR/08-40, Tunis, Tunisia. lachheb.jihene@yahoo.fr
Human Immunology
|August 7, 2007
Summary
Genetic variations in the RANTES gene promoter, specifically the -28 C/G and -403 G/A polymorphisms, are linked to an increased risk and severity of asthma. These RANTES gene variants influence airway obstruction in asthma patients.
Area of Science:
- Immunogenetics
- Respiratory Medicine
- Molecular Biology
Background:
- RANTES (regulated upon activation, normal T cells expressed and secreted) is a chemokine crucial for chemotaxis in allergic inflammation.
- Previous studies suggest a link between RANTES gene polymorphisms and asthma risk, particularly variants in the promoter region.
Purpose of the Study:
- To investigate the association between specific RANTES gene promoter polymorphisms (-28 C/G and -403 G/A) and haplotypes with asthma and its severity.
- To identify the role of RANTES gene variants in asthma predisposition and airway obstruction severity.
Main Methods:
- A case-control and family study design was employed.
- Genotyping of RANTES promoter polymorphisms (-28 C/G and -403 G/A) was performed.
- Haplotype analysis was conducted to assess combinations of polymorphisms.
Main Results:
- A significant association was found between the -28 C/G and -403 G/A RANTES promoter polymorphisms and asthma (p = 0.01 and p = 0.00175, respectively).
- The AC and AG haplotypes of RANTES polymorphisms were more prevalent in asthmatic individuals (p = 0.014 and p = 0.015, respectively).
Conclusions:
- The -28 C/G and -403 G/A polymorphisms in the RANTES promoter region are associated with asthma predisposition.
- These RANTES gene polymorphisms play a significant role in determining the severity of airway obstruction in asthma.
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