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Updated: Jul 13, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
The allele MICB 0050204, over-represented in the Caucasian population, has an additional exon resulting from a new
Jesús Martínez-Borra1, Luis Rodrigo, Sandra Rodríguez-Rodero
1Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Abstract:
We report that the allele MICB 0050204(1) allele, present in the majority of the Spanish population (70% of healthy controls) is characterized by the presence of an extra exon found between the sequence corresponding to exon 1 and 2. This is generated by a dinucleotide polymorphism in the first MICB intron that introduces a new splice junction, which can generate, by alternative splicing, transcripts with an additional exon. This new exon contains a premature stop codon and therefore the transcript does not produce a functional protein.
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