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Updated: Jul 13, 2026

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

Published on: March 24, 2020

Tethered cord syndrome.

Pankaj K Agarwalla¹, Ian F Dunn, R Michael Scott

¹Department of Neurosurgery, Children's Hospital of Boston, Boston, MA 02115, USA.

Neurosurgery Clinics of North America

|August 7, 2007

Summary

Tethered cord syndrome restricts spinal cord movement, causing potential hypoxia. This review covers congenital and acquired causes, clinical signs, and surgical treatments for this neurological condition.

Area of Science:

Neurology
Developmental Biology
Surgical Science

Background:

Tethered cord syndrome (TCS) involves spinal cord restriction, impacting movement and potentially causing distal hypoxia.
TCS can be congenital (primary) or acquired (secondary).

Purpose of the Study:

To provide a comprehensive overview of tethered cord syndrome.
To discuss embryology, etiologies, clinical manifestations, and management strategies.

Main Methods:

Review of embryological development related to spinal cord fixation.
Analysis of congenital and acquired causes of spinal cord tethering.
Compilation of clinical presentations and treatment options, including surgical interventions.

Main Results:

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Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

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Establishment of Central Cord Syndrome Model in C57BL/6J Mouse

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Detailed explanation of embryological origins of TCS.
Categorization of primary and secondary causes of spinal cord tethering.
Outline of diagnostic criteria and therapeutic approaches for various TCS entities.

Conclusions:

Understanding embryology is crucial for diagnosing congenital TCS.
Prompt diagnosis and appropriate surgical intervention can improve outcomes for patients with tethered cord syndrome.
Management requires consideration of specific etiologies, patient presentation, and potential surgical complications.