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A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Adiponectin and insulin sensitivity in primary aldosteronism
Francesco Fallo1, Paolo Della Mea, Nicoletta Sonino
1Department of Medical and Surgical Sciences, University of Padova, Padova, Italy. francesco.fallo@unipd.it
American Journal of Hypertension
|August 7, 2007
Summary
Primary aldosteronism is linked to lower adiponectin and insulin sensitivity, especially without metabolic syndrome. Correcting potassium and adiponectin may improve outcomes.
Area of Science:
- Endocrinology
- Metabolic Research
- Hypertension
Background:
- Primary aldosteronism (PA) exhibits high metabolic syndrome prevalence.
- Low adiponectin, an insulin-sensitizing adipokine, is a metabolic syndrome hallmark.
- This study investigates adiponectin and insulin sensitivity in PA versus essential hypertension.
Purpose of the Study:
- To evaluate the relationship between adiponectin and insulin sensitivity in primary aldosteronism.
- To compare these relationships in patients with and without metabolic syndrome.
- To contrast findings with low-renin essential hypertension (LREH) patients.
Main Methods:
- Forty PA patients and 40 matched LREH patients were studied.
- Patients with type 2 diabetes were excluded.
- Groups were stratified by the presence or absence of metabolic syndrome.
Main Results:
- Insulin resistance (HOMA index) was higher in PA than LREH only in the absence of metabolic syndrome.
- Adiponectin levels were lower in PA compared to LREH, a difference significant only in the absence of metabolic syndrome.
- Adiponectin inversely correlated with HOMA index and positively with potassium levels in both groups.
Conclusions:
- Lower adiponectin and insulin sensitivity in PA may stem from aldosterone excess and hypokalemia.
- Therapeutic correction of potassium and adiponectin could enhance insulin sensitivity.
- Improved insulin sensitivity may offer better cardiovascular protection in PA patients.
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