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[Risk of lithiasis and urolithiasis in children with unspecific inflammatory bowel disease]

Ryszard Makosiej1, Elzbieta Czkwianianc, Małgorzata Niedworok

  • 1Instytut Centrum Zdrowia Matki Polki, Łódź, Klinika Gastroenterologii. kpg@iczmp.edu.pl

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|August 8, 2007
PubMed

Insights

Children with inflammatory bowel disease (IBD) show a higher risk for urolithiasis and kidney stone formation. Early detection of crystallization risk factors in pediatric IBD patients is crucial for preventing symptomatic urolithiasis.

Area of Science:

  • Pediatric Nephrology
  • Gastroenterology
  • Urology

Context:

  • Urolithiasis is a complex condition with unclear etiopathogenesis.
  • Inflammatory Bowel Disease (IBD) encompasses ulcerative colitis and Crohn disease.
  • Pediatric IBD patients may have an increased risk of urolithiasis.

Purpose:

  • To evaluate the frequency of crystallization risk states and urolithiasis in children with IBD.
  • To assess the association between IBD and the development of kidney stones in pediatric patients.

Summary:

  • A study of 35 children (12-18 years) with IBD (ulcerative colitis and Crohn disease) and 20 controls was conducted.
  • Evaluations included urine analysis, crystallization risk index, urine microscopy, and ultrasound.
  • Results showed a high prevalence of erytrocyturia (77%), risk of oxalate-calcium (82.2%) and oxalate (17%) stone crystallization, and decreased magnesium levels (77%) in IBD children. Urolithiasis was present in 11.4% of IBD patients, significantly higher than controls (p < 0.01).

Impact:

  • Unspecific intestinal inflammations, like IBD, significantly influence the occurrence of crystallization risk states and symptomatic urolithiasis.
  • Findings highlight the need for proactive screening and management of urolithiasis risk in pediatric IBD patients.
  • This research contributes to understanding the systemic impact of IBD and informs clinical practice for improved patient outcomes.
Abstract

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