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Related Concept Videos

Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

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Related Experiment Video

Updated: Jul 13, 2026

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
09:50

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

[Histoclinic of "indeterminate colitis"].

Robert Koktysz1, Wojciech Kozłowski, Jerzy Trawiński

  • 1Wojskowy Instytut Medyczny w Warszawie, Zakład Patomorfologii CSK MON. robert67@wp.pl

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|August 8, 2007
PubMed
Summary

Indeterminate colitis lacks a clear definition and is often overused. This paper clarifies its appropriate use in diagnosing inflammatory bowel disease phenotypes.

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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

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Related Experiment Videos

Last Updated: Jul 13, 2026

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
09:50

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Pathology

Context:

  • Indeterminate colitis is a frequently used but poorly defined clinical term.
  • Current definitions rely on exclusionary criteria without confirmatory diagnostic tests.
  • This term is prevalent in clinical and morphological diagnostic practices.

Purpose:

  • To provide an expert opinion on the appropriate clinical application of the term 'indeterminate colitis'.
  • To review published data supporting the use and definition of indeterminate colitis.
  • To clarify the diagnostic criteria for indeterminate colitis in inflammatory bowel disease.

Summary:

  • Indeterminate colitis is an imprecise descriptor lacking a universal definition.
  • Despite its limitations, it may identify a distinct subgroup of inflammatory bowel disease patients.
  • The diagnosis requires explicit documentation of the applied exclusionary criteria.

Impact:

  • Promoting standardized diagnostic criteria for indeterminate colitis.
  • Improving the accurate classification of inflammatory bowel disease phenotypes.
  • Reducing ambiguity in clinical decision-making for colitis patients.