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Related Experiment Video

Updated: Jul 13, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

Neuropathy in multiple myeloma treated with thalidomide: a prospective study.

R Plasmati1, F Pastorelli, M Cavo

  • 1Dipartimento di Neuroscienze, Unità Operativa di Neurologia, Ospedale Bellaria, Bologna, Italy. rosaria.plasmati@ausl.bo.it

Neurology
|August 8, 2007
PubMed
Summary

Thalidomide effectively treats multiple myeloma (MM), but can cause mild peripheral neuropathy. This early side effect, often subclinical, occurred in most patients during treatment.

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Last Updated: Jul 13, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

Area of Science:

  • Hematology
  • Neuroscience
  • Pharmacology

Background:

  • Thalidomide is a key first-line treatment for multiple myeloma (MM).
  • Peripheral neurotoxicity is a significant limitation to thalidomide use in MM patients.
  • Understanding neuropathy in MM is crucial for optimizing treatment.

Purpose of the Study:

  • To investigate the incidence of both MM-related and thalidomide-induced neuropathy.
  • To assess neuropathy in 31 newly diagnosed MM patients receiving thalidomide therapy.
  • To correlate neuropathy with treatment parameters.

Main Methods:

  • Clinical and electrophysiologic evaluations were conducted.
  • 31 newly diagnosed MM patients received thalidomide (200 mg/day) for 4 months before transplantation.
  • Patients continued thalidomide post-transplantation for 3 months, with follow-up evaluations.

Main Results:

  • Four patients had mild MM-related neuropathy at baseline, slightly worsening with thalidomide.
  • 83% of patients developed mild, predominantly sensory, axonal polyneuropathy.
  • All patients achieved at least a partial response in their multiple myeloma.

Conclusions:

  • Mild peripheral neuropathy is a common, early side effect of thalidomide in MM.
  • The observed neuropathy was often subclinical and axonal.
  • High thalidomide doses and short treatment duration precluded correlation analysis with neuropathy severity.