Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glycoprotein Hydrogen-Bonding Hypothesis and Its Relationship with Other Mechanisms of Molecular Memory.

Current medicinal chemistry·2026
Same author

Quantum Consciousness: A Molecular Perspective Involving Glycoprotein-Tunnelling Hypothesis (GPTH).

Current medicinal chemistry·2026
Same author

A Unified Model of Consciousness: Glycoprotein Patterns in Memory Processes and Quantum Entanglement.

Current medicinal chemistry·2025
Same author

Biochemical and <i>In Silico</i> Studies on Triazole Derivatives as Tyrosinase Inhibitors: Potential Treatment of Hyperpigmentation Related Skin Disorders.

Medicinal chemistry (Shariqah (United Arab Emirates))·2024
Same author

Diclofenac prodrugs nanoparticles: An alternative and efficient treatment for rheumatoid arthritis?

International journal of pharmaceutics·2023
Same author

Protein Folding and Molecular Basis of Memory: Molecular Vibrations and Quantum Entanglement as Basis of Consciousness.

Current medicinal chemistry·2023

Related Experiment Video

Updated: Jul 13, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

New leishmanicidal physalins from Physalis minima.

M Iqbal Choudhary1, Sammer Yousuf, Samreen

  • 1H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan. hej@cyber.net.pk

Natural Product Research
|August 8, 2007
PubMed
Summary

Two novel physalins were isolated from Physalis minima and demonstrated potent leishmanicidal activity against Leishmania major promastigotes, offering potential new treatments for leishmaniasis.

More Related Videos

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major
08:17

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major

Published on: October 28, 2022

Related Experiment Videos

Last Updated: Jul 13, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major
08:17

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major

Published on: October 28, 2022

Area of Science:

  • Natural Product Chemistry
  • Parasitology
  • Medicinal Chemistry

Background:

  • Physalis minima Linn. (var. indica) is a plant species with a history of traditional medicinal use.
  • Physalins are a class of natural compounds found in Physalis species, known for diverse biological activities.
  • Leishmaniasis remains a significant global health concern, necessitating the discovery of novel therapeutic agents.

Purpose of the Study:

  • To isolate and characterize new physalin compounds from Physalis minima.
  • To evaluate the leishmanicidal activity of the isolated compounds against Leishmania major.

Main Methods:

  • Phytochemical investigation of Physalis minima using chromatographic techniques.
  • Structure elucidation of isolated compounds employing spectroscopic methods (e.g., NMR, MS).
  • In vitro leishmanicidal activity assay against Leishmania major promastigotes.

Main Results:

  • Two new physalins, designated as compounds 1 and 2, were successfully isolated and their structures determined.
  • Both novel physalins exhibited potent leishmanicidal activity against Leishmania major promastigotes.
  • The study identified specific structural features contributing to the observed bioactivity.

Conclusions:

  • The isolation of two new physalins from Physalis minima expands the known repertoire of these natural products.
  • The potent leishmanicidal activity of these compounds suggests their potential as leads for developing new anti-leishmanial drugs.
  • Further research into the mechanism of action and in vivo efficacy is warranted.