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Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
Published on: November 19, 2019
Single versus sequential saphenous vein grafting of the circumflex system: a flowmetric study
Francesco Onorati1, Francesco Pezzo, Antonio Esposito
1Cardiac Surgery Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy. frankono@libero.it
Insights
Sequential vein graft coronary artery bypass grafting (SV-CABG) on two obtuse marginal branches offers superior graft flow compared to single SV-CABG on one branch for circumflex lesions, reducing treatment failure.
Area of Science:
- Cardiovascular Surgery
- Vascular Grafting
- Coronary Artery Disease
Background:
- Critical circumflex (CX) artery lesions pose challenges in coronary artery bypass grafting (CABG).
- Optimal surgical strategy for single versus sequential vein grafts (SV-CABG) to obtuse marginal (OM) branches remains debated.
Purpose of the Study:
- To compare the efficacy of single SV-CABG on the best OM branch versus sequential SV-CABG on two OM branches for patients with proximal CX lesions.
Main Methods:
- Ninety patients with proximal CX lesions were prospectively randomized into two groups: single SV-CABG (n=45) or sequential SV-CABG (n=45).
- Graft performance was assessed using transit-time flowmetry (TTF) and graft flow reserve.
- Treatment failure was defined as recurrent angina, myocardial infarction, or need for reintervention.
Main Results:
- Sequential SV-CABG demonstrated significantly higher intraoperative maximum, mean, and minimum graft flows (p<0.001).
- Higher graft flow reserve was observed in the sequential SV-CABG group (p<0.001).
- Freedom from treatment failure was significantly better in the sequential SV-CABG group (97.5% vs. 88.7%, p=0.05).
Conclusions:
- Sequential SV-CABG to two OM branches provides superior graft flow and reserve compared to single SV-CABG.
- This approach is associated with a lower rate of mid-term treatment failure without increased perioperative risk.
Objective:
We sought to evaluate if patients with proximal critical circumflex (CX) lesions did better with single SV-CABG on the best obtuse marginal (OM), or with sequential SV-CABG on two OM branches.
Design:
Ninety patients were prospectively randomised to single SV-CABG on the best OM (sSV-CABG-45 patients; Group A) or to sequential SV-CABG on 2 OM (seqSV-CABG 45 patients; Group B). Transit-time flowmetry (TTF), and graft flow reserve were evaluated. Recurrent angina, acute myocardial infarction, readmission for coronary reintervention were defined "treatment failure" during follow-up.
Results:
SeqSV-CABG showed better intraoperative maximum (119.1+/-57.5 ml/min vs. sSV-CABG 62.4+/-29.6; p=0.001), mean (56.3+/-31.5 ml/min vs. 30.8+/-12.8; p=0.0001), minimum flow (22.8+/-9.2 ml/min vs. 11.8+/-8.9; p=0.001) and P.I. (0.71+/-0.4 vs.1.46+/-0.9; p=0.006). Graft flow reserve also proved to be higher (95.4+/-29.7 ml/min mean flow vs. sSV-CABG 42.3+/-15.2 ml/min mean flow; p=0.0001; flow reserve 1.72+/-0.99 vs 1.32+/-1.09; p=0.001) as well as freedom from treatment failure (97.5+/-0.5% vs 88.7+/-0.4%; p=0.05).
Conclusions:
SeqSV-CABG showed higher TTF flows, with no incremental risk for perioperative morbidity. Higher flows and graft flow reserve may allow lower treatment failure at mid-term follow-up.
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