Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide
M Cedzynski1, L Nuytinck, A P M Atkinson
1Laboratory of Immunobiology of Infections, Centre of Medical Biology, Polish Academy of Sciences, Lodz, Poland. mcedzynski@cbm.pan.pl
Abstract:
L-ficolin (also called ficolin-2, P35 or hucolin) is a soluble pattern recognition molecule of suspected importance in anti-microbial immunity. It activates the lectin pathway of complement and acts as an opsonin. l-ficolin, encoded by the FCN2 gene, recognizes microbial polysaccharides and glycoconjugates rich in GlcNAc or GalNAc. We report here data concerning four single nucleotide polymorphisms (SNPs) of the FCN2 gene and their relationship to l-ficolin serum concentrations. There are two pairs of SNPs in linkage disequilibrium: ss32469536 (located in promoter) with rs7851696 (in exon 8) and ss32469537 (promoter) with ss32469544 (exon 8). We selected groups possessing low or high serum l-ficolin concentrations (
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