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Characterizing Mediated Extracellular Electron Transfer in Lactic Acid Bacteria with a Three-Electrode, Two-Chamber Bioelectrochemical System
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Comparison and correlation between stinging responses to lactic acid and bioengineering parameters.

Susun An1, Eunyoung Lee, Seunghun Kim

  • 1Skin Research Institute, AmorePacific Corporation R&D Center, Yongin-si, Gyeonggi-do 446-729, Korea. ssan@amorepacific.com

Contact Dermatitis
|August 8, 2007
PubMed
Summary

Sensitive skin, or "stingers," exhibit a positive correlation between stinging responses and transepidermal water loss (TEWL), indicating a link to skin barrier function. Further research is needed to fully understand stingers

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Area of Science:

  • Cosmetic science
  • Dermatology
  • Skin physiology

Background:

  • Assessing cosmetic safety requires evaluating susceptible populations like "stingers."
  • Stingers are individuals prone to sensory effects (stinging, burning) from cosmetic contact.
  • Understanding stingers' skin characteristics is crucial for product development and safety.

Purpose of the Study:

  • To noninvasively measure skin biophysical parameters in stingers and non-stingers.
  • To investigate correlations between stinging responses and these skin parameters.
  • To identify objective markers for skin sensitivity in cosmetic users.

Main Methods:

  • Modified Lactic Acid Stinging Test (5% lactic acid) applied to 298 women.
  • Measurement of Transepidermal Water Loss (TEWL), skin hydration, sebum content, and pH.
  • Utilized bioengineering instruments in a controlled environment for precise measurements.

Main Results:

  • A positive correlation was found between stinging responses and TEWL.
  • No significant correlations were observed between stinging and skin hydration, sebum content, or pH.
  • Skin barrier function, indicated by TEWL, is related to the intensity of stinging reactions.

Conclusions:

  • Skin barrier function is linked to stinging sensitivity in cosmetic users.
  • TEWL may serve as a potential biomarker for identifying stingers.
  • Further studies are necessary to fully characterize stinger skin and the underlying pathogenesis.