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Published on: October 13, 2023
[Structural features of submandibular glands in the elderly]
1Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University.
Summary
Structural changes in elderly submandibular glands, including increased connective tissue and duct alterations, suggest reduced secretory function in individuals over 80 years old.
Area of Science:
- Histology
- Gerontology
- Anatomy
Context:
- Submandibular glands are crucial for saliva production.
- Aging significantly impacts organ structure and function.
- Understanding age-related changes in salivary glands is vital for oral health.
Purpose:
- To investigate age-related structural modifications in human submandibular glands.
- To compare histological features between younger elderly ( <80) and higher elderly (≥80) individuals.
- To correlate structural changes with potential alterations in secretory function.
Summary:
- Increased intralobular/interlobular connective tissue observed in the higher elderly group.
- Epithelial cells of the striated portion shorten, and terminal portions decrease in number and size.
- Alcian Blue staining reveals altered mucin content in ductal cells, with a decrease in the higher elderly.
- These findings suggest a decline in the secretory capacity of submandibular glands with advanced age.
Impact:
- Provides detailed insights into the aging process of submandibular glands.
- Highlights potential causes for reduced salivary flow in the elderly.
- Informs clinical approaches to managing age-related xerostomia (dry mouth).
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