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Updated: Jul 13, 2026
08:13
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
Summary
Insulin resistance (IR) is a critical issue in internal pathology. This review explores its history, clinical features, and proposes a two-type classification based on hyperglycemia and acetonuria levels.
Area of Science:
- Endocrinology
- Internal Medicine
- Pathophysiology
Background:
- Insulin resistance (IR) has been a significant challenge in internal pathology for 80 years.
- Understanding IR is crucial for managing metabolic syndrome and related conditions.
Purpose of the Study:
- To provide a historical overview of insulin resistance in Russian and global medical practice.
- To detail the clinical features, etiological factors, and pathogenetic mechanisms of IR.
- To propose a novel classification for insulin resistance.
Main Methods:
- Literature review covering historical aspects of IR.
- Analysis of clinical features and etiological factors associated with IR.
- Exploration of pathogenetic pathways leading to IR and metabolic syndrome.
Main Results:
- Historical evolution of IR understanding is presented.
- Clinical manifestations and contributing factors to IR are discussed.
- A new classification of IR is proposed, distinguishing two types based on hyperglycemia, glucosuria, and acetonuria.
Conclusions:
- Insulin resistance remains a complex and vital area of internal medicine.
- The proposed classification offers a refined approach to understanding IR phenotypes.
- Further research into psychogenic and neurohumoral mechanisms is warranted.
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