[Insulinoresistance in internal diseases]

For the 80 years of its history, the problem of isulinoresistance (IR) in internal pathology has remained among important ones. The article covers historical aspects of this problem in Russian and world practice, clinical features of IR in connection with etiological factors, and the main pathogenetic mechanisms that lead to IR and metabolic syndrome. The author suggests that IR should be classified into two types, the first of which is hyperglycemia and glucosuria with transient acetonuria, and the second is higher hyperglycemia with mild glucosuria or aglucosuria and persistent acetonuria. Psychogenic and neurohumoral mechanisms of the development of IR are covered as well.