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Serum Reg-Ialpha is not suitable marker of metabolic syndrome
D Stejskal1, M Karpisek, D Horakova
1Department of Laboratory Medicine and Metabolic and Diabetes Outpatient Centre, Sternberk Hospital, Czech Republic. david.stejskal@quick.cz
Background:
Reg-1alpha plays a role in various types of tissue regeneration.
Aim:
To evaluate serum Reg-1alpha for the diagnosis of metabolic syndrome.
Methods:
14 non-obese, healthy subjects and 15 individuals with metabolic syndrome were studied. Anthropometric and laboratory analysis in sera (Body Mass Index--BMI, insulin, triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, aglucose, Quicki calculation, Reg-1alpha) were performed.
Results:
Reg-1alpha levels did not differ between subjects with metabolic syndrome and healthy subjects (means 597.7 vs. 631.1 ng/l, p < 0.01) and positively correlated only with fasting glucose (r = 0.34; p < 0.01) and age (r = 0.38; p < 0.01); Reg-1alpha correlated even after adjustment to age. Reg-lalpha concentrations did not differ in men and women.
Conclusions:
Our study, for the first time, indicates that serum Reg-1alpha is not useful for the diagnosis of metabolic syndrome (Tab. 3, Ref. 7).
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