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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: Jul 13, 2026

A Standardized Pig to Macaque Heterotopic Heart Xenotransplantation Model

A Standardized Pig to Macaque Heterotopic Heart Xenotransplantation Model

Published on: November 4, 2025

An update on xenotransplantation.

E Cozzi¹, M Seveso, S Hutabba

¹CORIT (Consorzio per la Ricerca sul Trapianto d'Organi), Padua, Italy. emanuele.cozzi@unipd.it

Veterinary Research Communications

|October 10, 2007

Summary

Pig organ transplantation into humans shows promise for organ shortages. Research focuses on overcoming immune rejection and ensuring safety, with preclinical studies demonstrating several months of survival in primates.

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Xenotransplantation of Human Stem Cells into the Chicken Embryo

Xenotransplantation of Human Stem Cells into the Chicken Embryo

Published on: July 11, 2010

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Last Updated: Jul 13, 2026

A Standardized Pig to Macaque Heterotopic Heart Xenotransplantation Model

A Standardized Pig to Macaque Heterotopic Heart Xenotransplantation Model

Published on: November 4, 2025

Xenotransplantation of Human Stem Cells into the Chicken Embryo

Xenotransplantation of Human Stem Cells into the Chicken Embryo

Published on: July 11, 2010

Area of Science:

Organ transplantation research
Immunology
Physiology
Biosafety

Background:

The critical shortage of human organs for transplantation necessitates alternative solutions.
Xenotransplantation, specifically using pig organs, is a potential strategy to address this deficit.
Significant immunological, physiological, and biosafety challenges must be overcome for successful xenotransplantation.

Purpose of the Study:

To review the current status of xenotransplantation, focusing on pig-to-primate organ transplantation.
To highlight key immunological, physiological, and biosafety considerations.
To assess the progress and future directions in the field.

Main Methods:

Review of current research on xenotransplantation, particularly pig organs in primates.
Analysis of immunological barriers, focusing on acute humoral xenograft rejection (AHXR).
Evaluation of physiological compatibility and biosafety aspects.

Main Results:

Acute humoral xenograft rejection (AHXR) remains a primary immunological hurdle.
Preclinical studies show porcine xenografts can sustain non-human primates for months.
Absence of insurmountable physiological incompatibilities and reassuring biosafety findings have been reported.

Conclusions:

Advancements in genetic engineering, immunosuppression, and tolerance induction are expected to improve xenograft survival.
Further preclinical data on physiology, efficacy, and safety in primate models are crucial.
Clinical xenotransplantation is not yet recommended pending comprehensive data generation.