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Related Concept Videos

Adhesion01:14

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...

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Related Experiment Video

Updated: Jul 13, 2026

Creation of Abdominal Adhesions in Mice
06:44

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

[Can dexpanthenol prevent peritoneal adhesion formation? An experimental study].

Yusuf Akdeniz1, Omer Ridvan Tarhan, Ibrahim Barut

  • 1Department of General Surgery, Medicine Faculty of Süleyman Demirel University, Isparta, Turkey.

Ulusal Travma Ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery : TJTES
|August 9, 2007
PubMed
Summary

Dexpanthenol administered intraperitoneally may reduce peritoneal adhesion formation. This is likely due to alterations in peritoneal fibrinolytic activity, suggesting a potential therapeutic benefit.

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Last Updated: Jul 13, 2026

Creation of Abdominal Adhesions in Mice
06:44

Creation of Abdominal Adhesions in Mice

Published on: August 27, 2016

A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation
03:47

A Translational Surgical Porcine Model for Postoperative Intra-Abdominal Adhesion Formation

Published on: March 13, 2026

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage
04:25

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

Published on: April 28, 2022

Area of Science:

  • Surgical research
  • Wound healing mechanisms
  • Peritoneal biology

Context:

  • Peritoneal adhesions are a common complication following abdominal surgery.
  • Intrinsic peritoneal fibrinolytic activity normally prevents adhesion formation.
  • Ischemic peritoneal injuries can impair this natural defense mechanism.

Purpose:

  • To investigate the effect of dexpanthenol on peritoneal adhesion formation in a rat model.
  • To determine if dexpanthenol influences key components of the peritoneal fibrinolytic system.

Summary:

  • Abrasion of the rat cecum induced peritoneal adhesions.
  • Intraperitoneal dexpanthenol administration significantly reduced adhesion formation compared to controls.
  • Dexpanthenol increased tissue plasminogen activator (tPA) activity and concentration, suggesting modulation of fibrinolysis.

Impact:

  • Dexpanthenol, particularly via intraperitoneal administration, shows promise in reducing peritoneal adhesions.
  • The findings suggest a potential role for dexpanthenol in managing post-surgical peritoneal complications.
  • Further research may explore dexpanthenol as an adjunct therapy to prevent adhesions.