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Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
Published on: November 26, 2015
Prostatic intraepithelial neoplasia: recent advances.
1Department of Pathology, The Methodist Hospital, Weill Cornell University School of Medicine, 6565 Fannin St, Room 227 (Main Building), Houston, TX 77030, USA. aayala@tmh.tmc.edu
Archives of Pathology & Laboratory Medicine
|August 9, 2007
Summary
Prostatic intraepithelial neoplasia (PIN) is a precancerous condition of the prostate. Identifying PIN patterns aids in diagnosing prostate cancer risk and guides patient management.
Area of Science:
- Uropathology
- Oncology
- Molecular Pathology
Background:
- Prostatic intraepithelial neoplasia (PIN) is a recognized precancerous condition of the prostate.
- Atypical adenomatous hyperplasia (adenosis) is another putative precursor, but PIN is more established.
Purpose of the Study:
- To review recent advancements in understanding PIN.
- To refine diagnostic criteria and differential diagnosis for PIN.
Main Methods:
- Literature review.
- Analysis of clinical experience.
Main Results:
- Ductal/acinar epithelial changes like nuclear enlargement and luminal complexity characterize PIN.
- High-grade PIN (HGPIN) presents in patterns: tufting, micropapillary, cribriform, and flat.
- HGPIN shares age-related incidence, peripheral zone prevalence, and molecular markers with prostate cancer.
Conclusions:
- PIN represents an intermediate stage between benign epithelium and invasive carcinoma.
- HGPIN identifies patients at risk for prostate carcinoma.
- Increased identification of HGPIN with extended biopsies may reduce missed concurrent prostate cancer.
