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Related Concept Videos

Ethics and Bioethics01:22

Ethics and Bioethics

Ethics is a philosophical study of moral actions. Ethics attempts to determine what is valuable for individuals and society. It examines the rational justification of moral judgments and analyzes what is morally just, fair, and right. Bioethics is a sub-discipline of applied ethics that analyzes the philosophical, social, and legal issues in life sciences and medicine. Ethical theories serve as a foundation for decision-making and represent the viewpoints from which people seek direction. They...
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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
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Ethical Dilemmas II01:30

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Ethical Dilemmas I01:17

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Ethical dilemmas in nursing are of utmost importance, as they often arise from the tension between adhering to core ethical principles and the practical realities of healthcare delivery. These dilemmas require nurses to navigate complex situations where competing ethical considerations pull them in different directions.
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Working with Human Tissues for Translational Cancer Research
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Published on: November 26, 2015

Should research ethics triumph over clinical ethics?

Michael H Kottow1

  • 1School of Public Health, University of Chile, Santiago, Chile. kottow@terra.cl

Journal of Evaluation in Clinical Practice
|August 9, 2007
PubMed
Summary

Evidence-based medicine (EBM) faces challenges in clinical practice due to strict research ethics that may conflict with patient welfare. This conflict arises from prioritizing scientific rigor over therapeutic obligations, hindering EBM adoption.

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Area of Science:

  • Medical Ethics
  • Clinical Research Methodology
  • Evidence-Based Medicine

Background:

  • Evidence-based medicine (EBM) and randomized clinical trials (RCTs) have not fully translated into widespread medical practice.
  • Practitioners express reluctance in applying research findings due to perceived conflicts with clinical realities.

Purpose of the Study:

  • To explore how rigid adherence to investigative ethics by scientists and sponsors impacts the application of EBM.
  • To examine the consequences of prioritizing scientific methodology over patient welfare in clinical research.

Main Methods:

  • Exploration of ethical considerations in scientific research protocols.
  • Analysis of the distinction between research ethics and clinical ethics.
  • Examination of the concept of the 'therapeutic fallacy' in clinical trials.

Main Results:

  • Insistence on exclusive adherence to investigative ethics, focused on informed consent and risk minimization, can alienate practitioners.
  • The 'therapeutic fallacy' is perpetuated when research protocols disregard patient welfare, particularly when using placebos against existing therapies or ignoring equipoise.
  • A disconnect between scientists' and practitioners' priorities further impedes EBM's integration into healthcare.

Conclusions:

  • Strict adherence to research ethics, detached from therapeutic obligations, undermines the practical utility of EBM.
  • Reconciling the ethical demands of scientific investigation with the therapeutic duties of clinicians is crucial for effective EBM implementation.
  • Addressing the differing priorities between researchers and clinicians is essential for improving the reception of EBM in healthcare professions.