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The TCF7L2 locus and type 1 diabetes.
Hui-Qi Qu1, Constantin Polychronakos
1Endocrine Genetics Lab, The McGill University Health Center, Montreal Children's Hospital, Montréal, Québec, Canada. hui.qi.qu@mail.mcgill.ca
BMC Medical Genetics
|August 9, 2007
Summary
Genetic variations in TCF7L2, linked to type 2 diabetes (T2D), were investigated for type 1 diabetes (T1D) risk. This study found no association between TCF7L2 and T1D, suggesting different etiological mechanisms.
Area of Science:
- Genetics
- Endocrinology
- Immunology
Background:
- TCF7L2 gene variations are associated with type 2 diabetes (T2D) and reduced insulin secretion.
- TCF7L2 is located on human chromosome 10q25.3.
- The role of TCF7L2 in type 1 diabetes (T1D) remains unclear.
Purpose of the Study:
- To investigate the potential genetic association between TCF7L2 and T1D.
- To determine if the T2D-associated SNP rs7903146 in TCF7L2 influences T1D risk or age of onset.
Main Methods:
- Genotyping of the TCF7L2 SNP rs7903146 in 886 T1D nuclear families.
- Participants were of mixed European descent.
Main Results:
- No significant association was found between rs7903146 and T1D.
- The SNP rs7903146 did not demonstrate an effect on the age of onset for T1D.
Conclusions:
- The TCF7L2 gene, implicated in T2D pathogenesis, does not appear to play a role in the etiology of T1D.
- Mechanisms underlying T2D related to TCF7L2 are likely distinct from those in T1D.
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