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[Gene expression profile changes in oral verrucous carcinoma and oral squamous cell carcinoma]
Zhan-gui Tang1, Su-ping Zhao, Lei Zhang
1Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410078, China. tangzhangui@yahoo.com.cn
Objective:
To determine the difference in the gene expression between human oral verrucous carcinoma (OVC) and oral squamous cell carcinoma (OSCC).
Methods:
cDNA chip was used to detect the mRNA of cancer tissue from 4 OVC and 4 OSCC. After profile blotted and handled by bioinformation, the gene expression of these two kinds of lesions was examined.
Results:
Using the BioStarH-40 profile, 593 different expression of genes was found. The rate of different genes was 15.2%, of which the expression of 283 genes increased (59 genes significantly increased) and 310 genes decreased (98 genes significantly decreased) in OVC tissue than that in OSCC.
Conclusions:
The gene expression of OVC and OSCC was different, which many contribute to the different biological behavior of these two kinds of lesions.
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