Related Experiment Video
Updated: Aug 19, 2026
Demonstration of the Rat Ischemic Skin Wound Model
Published on: April 1, 2015
Evaluation of wound-healing potential of Catharanthus roseus leaf extract in rats
B S Nayak1, M Anderson, L M Pinto Pereira
1Department of Pre Clinical Sciences, Biochemistry Unit, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago. snayak@fms.uwi.tt
Abstract:
Rats treated with 100 mg /kg/day of the Catharanthus roseus ethanol extract had high rate of wound contraction significantly decreased epithelization period, significant increase in dry weight and hydroxyproline content of the granulation tissue when compared with the controls. Wound contraction together with increased tensile strength and hydroxyproline content support the use of C. roseus in the management of wound healing.
