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Published on: March 27, 2018
Dopamine D2/D3 receptor binding in the anterior cingulate cortex and executive functioning
Ville Lumme1, Sargo Aalto, Tuula Ilonen
1Turku PET Centre, University of Turku, c/o Turku University Central Hospital, PO Box 52, FIN-20521 Turku, Finland.
Abstract:
The objective was to investigate the association between extrastriatal dopamine D(2)/D(3) receptor binding and performance on the Wisconsin Card Sorting Test (WCST), a measure of executive functioning. Thirty-two healthy volunteers performed the WCST and underwent positron emission tomography and a high-affinity D(2)/D(3) receptor tracer, [(11)C]FLB 457. All WCST error parameters, in particular nonperseverative errors, correlated positively with [(11)C]FLB 457 binding in the cognitive division of the right anterior cingulate cortex. An independent voxel-based receptor parametric mapping analysis confirmed these findings. The results indicate that executive functioning in healthy volunteers is modulated by D(2)/D(3) receptors in the anterior cingulate cortex.
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