Related Experiment Video

Updated: Jul 13, 2026

Expression and Purification of Nuclease-Free Oxygen Scavenger Protocatechuate 3,4-Dioxygenase
10:14

Expression and Purification of Nuclease-Free Oxygen Scavenger Protocatechuate 3,4-Dioxygenase

Published on: November 8, 2019

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.

Jens Köditz1, Jutta Nesper, Marieke Wottawa

  • 1Department of Heart and Circulatory Physiology, Center of Physiology and Pathophysiology, Georg-August University Göttingen, Göttingen, Germany.

Blood
|August 9, 2007
PubMed
Summary

Activating transcription factor-4 (ATF-4) protein levels are regulated by oxygen through prolyl-4-hydroxylase domain 3 (PHD3). This oxygen-sensing mechanism influences cell fate and adaptive responses.

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