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Stretch-induced increase of resting intracellular calcium concentration in single guinea-pig ventricular myocytes
J Y Le Guennec1, E White, F Gannier
1Laboratoire d'Electrophysiologie et de Pharmacologie cellulaires, Université de Tours, Faculté des Sciences, France.
Experimental Physiology
|November 1, 1991
Abstract:
Single guinea-pig ventricular myocytes were loaded with the fluorescent Ca2+ indicator Indo-1 AM and stretched by carbon fibres. Stretching increased resting tension. Sarcomere lengths were increased by 2-18%. It was observed that a stretch increased resting [Ca2+]i in seven out of eight cells. The change in [Ca2+]i increased with the size of the stretch and returned to pre-stretch levels on return to resting cell length. These observations suggest a means by which changes in resting muscle length can modify the contractile state of cardiac muscle.